I'm all too aware of the problems.
我实在太明白这些问题了。
We have encountered major problems.
我们遇上了大问题。
These problems are closely related.
这些问题都是密切相关的.。
The task poses no special problems.
这项任务不会造成特别的问题。
Are there any problems at your end?
你那边有什么问题吗?