Hydroxyquinoline derivatives are a class of heterocyclic aromatic compounds, usually white or pale yellow crystals. The 8-hydroxyquinoline derivatives are widely used in the fields of pharmaceutical synthesis and chemical analysis, so it is important to explore its synthetic methods. The discovery process can help to synthesize the drug in the future. 5, 7 - dibromo - 8 - hydroxyquinoline and bromine - 5 - chloro - 7-8 - hydroxyquinoline, 8 - hydroxyquinoline derivatives of two substances, can be used as an analytical reagent a wide range of determination and separation of metal ions, is also a kind of extremely important printing and dyeing industry and pharmaceutical intermediates. Paper respectively by 2, 4 - two bromine phenol and 2 - bromine - 4 - chlorine phenol as raw material to design synthetic route, was synthesized via nitration, reduction, cyclization, a series of 5, 7 - dibromo - 8 - hydroxyquinoline and bromine - 5 - chloro - 7-8 - hydroxyquinoline. Finally, the final target product is obtained by the 1H NMR confirmation structure.
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